Evaluación de puntos críticos en el consumo de medicamentos anticonceptivos hormonales, en estudiantes de la Universidad Nacional de Colombia: sede Bogotá 2008-2012

Las poblaciones humanas se exponen continuamente al consumo de medicamentos ya sea para recuperar o para mantener determinadas condiciones de vida, a través de un resultado terapéutico. Objetivo: Caracterizar y analizar los puntos críticos en el consumo de Anticonceptivos Hormonales (AH), en una población femenina universitaria. Materiales y Métodos: Estudio observacional, descriptivo: Los puntos críticos inherentes a la prescripción se evaluaron a partir del 46% -354- de las historias clínicas y del 100% de prescripciones físicas para un año y a partir de encuestas del 71% de prescriptores voluntarios, los puntos críticos relacionados al paciente se evaluaron a partir de encuestas del 21% de voluntarias respondientes y la calidad biofarmacéutica se estableció para tres marcas de AH mas prescrito en el área de salud Estudiantil de la Universidad Nacional. Resultados: Población entre 18 y 31 años; 91,46% soltera; 45,95% estrato socioeconómico 3; Respecto al patrón de prescripción: 97,32% Prescripción de AHC de los que el 39,08% son AOC de cuarta generación. La calidad terapéutica de la prescripción en las 17 condiciones médicas propias de la población, presentó un 82,357% de cumplimiento frente a CMEA de la OMS, el 17,65% prescribió ACH método categoría dos frente a AOPS de categoría I. Los principales desaciertos en cuanto a aspectos de forma indican que el 17,99% refieren algún error relacionado con la concentración, El DCI es empleado en un 98,8%. Respecto a las percepciones de uso: 76,79% no utilizan doble protección AH-condón (AB); el confía en el consejo médico para iniciar la TAC. Respecto al patrón de uso: El 38,24% ha tenido una exposición a anticonceptivos de entre 1 y dos años. Con los medicamentos sobrantes la conducta más común es dejarlo guardado con otros medicamentos en un 46,45%. Respecto a la adherencia: y al test de auto cumplimiento el 68,64% son no cumplidoras. Respecto a la percepción del programa: Hay un cumplimiento de los requisitos normativos en un 86%, se identifican fortalezas en el personal médico y administrativos y oportunidades de mejora en la difusión y cobertura del servicio. Respecto a la calidad Biofarmacéutica para intercambiabilidad de los anticonceptivos en estudio, se encontró que una marca si es intercambiable con el medicamento tomado de referencia y la otra no. Conclusiones: Se encontraron factores positivos como el cumplimiento frente a parámetros normativos; También se encontraron factores negativos como: baja adherencia, percepciones erróneas ante el uso simultaneo de AH-AB, actitudes negativas respecto a la disposición final de AH y falta de equivalencia terapéutica entre medicamentos del mismo principio activo.Abstract. Human populations are continuously exposed to drug use to either recover or maintain certain living conditions, through a therapeutic result. Objective: To describe and analyze the critical points in the consumption of Hormonal Contraceptives (AH ) in a female college population. Materials and Methods: An observational, descriptive study: The critical points are inherent to the procedure were evaluated from 46% of the medical records -354- and 100% physical requirements for a year and from surveys of 71% of volunteers prescribers points related to critical patient surveys assessed from 21 % voluntary and biopharmaceutical quality was established for three brands of AH prescribed more in the area of Student health at the National University. Results: Population between 18 and 31 years; 91.46 % single; Socioeconomic 45.95% 3; Regarding the prescription pattern: Prescription AHC 97.32 % of which 39.08 % are fourth generation COCs . The therapeutic quality of prescribing in the population own 17 medical conditions , presented a 76.47 % compliance against the medical eligibility criteria for contraceptive use WHO. Main mistakes in terms of how aspects indicate that 17.99 % reported an error related to the concentration , the DCI is used in 98.8 %. For perceptions of usage: 76.79 % used no condom AH- double protection (AB ); the trust medical advice to start the TAC . Regarding the usage pattern : The 38.24% have had an exposure to contraceptives between 1 and two years. With leftover drugs the most common behavior is left stored with other medicines in a 46.45 %. Regarding adherence: test and the self fulfilling 68.64 % are non-compliant . Regarding the perception of the program : There is compliance with regulatory requirements by 86 % , strengths identified in the medical and administrative staff and opportunities for improvement in the dissemination and service coverage. Regarding the interchangeability of Biopharmaceutical quality contraceptives study found that if a brand is interchangeable with the reference drug taken and the other not . Conclusions : Positive factors as compliance against regulatory parameters were found ; Low adhesion , misperceptions before the simultaneous use of AH- AB, negative attitudes towards the disposal of AH and lack of therapeutic equivalence between drugs of the same active principle as negative factors were also found.Maestrí

Quality assessment of sardines during storage by measurement of fluorescent compounds

5 páginas, 2 figuras, 5 tablasSardine alterations during chilled storage (0°C) were investigated by measuring the fluorescence ratio between two excitation/emission maxima (393/463 nm, 327/415 nm) and compared with common quality indices. Sardines were also maintained at 15°C to accelerate all reactions occurring at 0°C. Other quality indices (total volatile base-nitrogen, free fatty acids, formation of conjugated dienes, and thiobarbituric acid values) were determined and the use of the fluorescence ratio (fluorescence shift, δF) was analyzed. A high correlation was found between the δF and the total volatile base-nitrogen (r = 0.93, at 0°C; r = 0.92, at 15°C).Xunta de Galicia (Project XUGA 402 01B93).Peer reviewe

Differential lipid damage in various muscle zones of frozen hake (Merluccius merluccius)

5 páginas, 5 tablas, 1 figura.-- The final publication is available at www.springerlink.comA comparison of the lipid damage produced in different hake zones was carried out during frozen storage at –11 and –18 7C. Three light muscle zones and the dark muscle were considered. Lipid oxidation [conjugated dienes; thiobarbituric acid index (TBA-i); fluorescence formation] and hydrolysis (free fatty acids, FFA) were determined. The most predominant lipid damage in all zones was hydrolysis, at the end of storage reaching values of about 40% (for the light muscle zones) and 12% (for the dark muscle) of the total lipids at –11 7C. Significant (P~0.05) correlation value (rp0.67–0.85) relationships between the frozen storage time and the FFA content were obtained for the four muscle zones at both temperatures. A comparison of the regression lines slopes in the different zones showed that a lower (P~0.05) lipolitic activity was produced in the dark muscle compared to the three light zones at both temperatures. A low lipid oxidation development was produced in the three light muscle parts, so that no significant differences between them could be assessed. However, the dark muscle showed a higher oxidation development (TBA-i and fluorescence formation) as a result of a higher lipid content and the presence of prooxidant constituents.European Community, Research Projects FAIR-CT95–1111 and AIR 3-CT94–1921.Peer reviewe

Andamios porosos (apatita/colágeno) de origen marino para aplicaciones biomédicas

1 póster presentado en las III Xornadas de Investigación BioIntegraSaúde 2015, Vigo 16 xuño 2015.-- E. López-Senra ... et al.FP7/REGPOT-2012-2013.1 (nº 316265, BIOCAPS); UE-INTERREG 2011-1/164 MARMED; Ministerio de Ciencia e Innovación (Project MAT2010-18281)Peer reviewe

Notas para el itinerario de Alfonso XI, en el período de 1344 a 1350.

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Madrid, residencia de la Corte Real en la primera mitad del siglo XIV.

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Characterization of Collagen from Different Discarded Fish Species of the West Coast of the Iberian Peninsula

13 páginas, 5 tablas, 3 figuras.-- This is an open Access article. Non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly attributed, cited, and is not altered, transformed, or built upon in any way, is permitted. The moral rights of the named author(s) have been asserted.Skin collagen of six discarded fish species was analyzed and compared. Acid soluble collagen (ASC) was extracted; a characteristic sodium dodecyl sulfate- polyacrylamide gel electrophoresis (SDS-PAGE) profile for type I collagen was obtained, except for Chimaera mostrosa. Contents of collagen calculated from HPro (31.85% average) were higher than those determined from ASC extracts (17.75% average), with Galeus spp. being the species with the higher percentage. Amino acid analysis revealed the typical composition of collagen, with very few differences among species. Specific profiles were obtained after protease digestion. Denaturation temperature of ASC correlated well with imino and hydroxyproline contents. Results demonstrate the feasibility of using the obtained collagens in different industrial applicationsThis work was funded by European Union FEDER POCTEP Project 0330_IBEROMARE_1_P, European Union FEDER Atlantic Area Project MARMED-2011-1/164, Xunta de Galicia Project 10TAL011E, and a contract with the “Cooperativa de Armadores del Puerto de Vigo” and FROM (Ministery of Environment, Rural and Maritime Affairs, Spain)Peer reviewe

Valorization alternatives for a highly unused biomass (Small-spotted catshark discards and by-products) in the framework of LIFE iSEAS project

1 póster presentado en el Total Food Conference 2014 Science and technology for the economic and sustainable exploitation of agri-food chain wastes and co-products, Norwich, Uk, 11-13 November (2014)The authors thank the finnancial support received from the LIFE + Program of the European Union (LIFE Project‐ LIFE13 ENV/ES/000131N

Evaluation of a fast method based on the presence of two restriction sites in the mitochondrial ND5 (mt ND5) gene for the identification of scomber species

9 páginasThe purpose of this work was to evaluate the suitability of a method based on the presence of two restriction sites (for Hae III and Hindf I) in the mitochondrial NADH dehydrogenase subunit 5 (mt ND5) gene to identify Scomber species. The evaluation was performed on 144 reference and market samples by sequencing of the entire 505-bp fragment of the mt ND5 gene and of a 464-bp fragment of the Kocher fragment of the cytochrome b gene (mt Cytb). Sequence analysis of any of the two fragments allows the identification of each of the four Scomber species, but S. japonicus and S. colias had the same restriction sites at the ND5 amplicon and would not have been differentiated by this analysis. Similarly, loss of the Hae III site in some S. scombrus individuals would have misidentified them as not being Scomber. All the market products were correctly labeled except one acquired in Spain labeled as originating in the Atlantic and containing S. japonicusPeer reviewe